The 3-Step Regenerative Protocol
A physician-guided, multi-day clinical process designed to reduce inflammatory burden and support the body’s regenerative signaling.
Prepare the Biological Environment
Protect and guide cellular signaling
Support targeted tissue regeneration
Prepare the Biological Environment
Protect and guide cellular signaling
Support targeted tissue regeneration
learn more
Designed to address regeneration at multiple levels
Systemic reset
Helps calm widespread inflammation in the body, creating a healthier environment so regenerative therapies work more effectively.
Targeted repair
Focuses on areas of the body that need healing most, supporting recovery at the tissue level based on individual clinical findings.
Biological coordination
Supports the body’s natural healing signals so cells, immune responses, and repair processes work together more efficiently.
What stood out was how structured and professional everything felt. The evaluation, the explanations, and the level of care made it clear this was a serious medical environment.
The program is called Harmony for women and Enhancement for men… and I recommend that for everyone — out of ten, everyone a twelve.
“I couldn’t even believe this place existed… the whole building is great, and the attention — I have no words to describe it.”
How the protocol works
A step-by-step approach designed to support the body’s natural regenerative processes.
Intended physiological effects
Systemic reset
Supports the body in moving away from ongoing inflammatory stress and restoring a more balanced internal environment.
Targeted repair
Helps immune cells and tissues exchange signals more clearly, supporting coordinated responses during recovery.
Biological coordination
Encourages the body’s natural repair processes at the tissue level through improved biological coordination.
These describe how the body may respond during and after the protocol. Individual experiences may vary.
What sets us apart
Multi-stage delivery
This protocol is structured as a sequenced, multi-step intervention rather than a single treatment event.
Biological sequencing
Each therapeutic step is administered in a defined biological order to support coordination and efficacy.
Targeted migration
Cell populations are selected for their ability to respond to injury and inflammation signaling.
In-house laboratory
All cellular preparation and verification are performed within RMI’s controlled laboratory environment.
What guides patient care at RMI
No off-the-shelf protocols
Every treatment plan is developed around the patient. Clinical decisions are guided by evaluation and physician oversight.
Built for biological impact
Each treatment delivers a carefully calibrated, high-volume dose of expanded cells.
Immune-privileged approach
The cells used are immune-privileged and well tolerated without immunosuppression.
No off-the-shelf protocols
Every treatment plan is developed around the patient. Clinical decisions are guided by evaluation and physician oversight—not pre-set or generalized protocols.
Built for biological impact
Each treatment delivers a carefully calibrated, high-volume dose of expanded cells, designed to meaningfully support immune balance, signaling, and recovery processes.
Immune-privileged approach
The cells used are immune-privileged, meaning they are well tolerated without the need for donor matching or immunosuppression, supporting a safer treatment experience.1
What to expect
Clinical review & program design
Every patient begins with a physician-led review of medical history, labs, and goals. This consultation helps determine suitability and allows the care team to tailor the protocol to individual needs.
Plasma exchange
After medical consultation and bloodwork, patients arrive for intake and vitals. Therapeutic Plasma Exchange (TPE) removes inflammatory substances. Duration: 2–3 hours.
Cellular infusion
Expanded MSCs are administered intravenously, followed by MUSE cells. This sequence primes the biological terrain for optimal cell retention. Nutritional IV included.
Discharge review
A final medical evaluation is completed prior to discharge. Patients receive detailed post-care guidance, follow-up recommendations, and ongoing support instructions.
Ongoing clinical monitoring
Following discharge, patients remain under clinical oversight. The care team reviews progress, addresses questions, and provides guidance to support recovery over time.
What to expect
Plasma exchange
After medical consultation and bloodwork, patients arrive for intake and vitals. Therapeutic Plasma Exchange (TPE) removes inflammatory substances. Duration: 2–3 hours.
Discharge review
A final medical evaluation is completed prior to discharge. Patients receive detailed post-care guidance, follow-up recommendations, and ongoing support instructions.
Clinical review & program design
Every patient begins with a physician-led review of medical history, labs, and goals. This consultation helps determine suitability and allows the care team to tailor the protocol to individual needs.
Cellular infusion
Expanded MSCs are administered intravenously, followed by MUSE cells. This sequence primes the biological terrain for optimal cell retention. Nutritional IV included.
Ongoing clinical monitoring
Following discharge, patients remain under clinical oversight. The care team reviews progress, addresses questions, and provides guidance to support recovery over time.
Trusted by industry leaders
Troy Hoffman
The experience, the Doctors on staff . The before and after care . They have it nailed down here .. compared to all the places I went in Cancun and Baja peninsula.
Smith Johnston
Dr. Urzola and Dr. Giampapa have built what I consider the leading regenerative medicine institute in the world. It’s called Regenerative Medicine Institute in Costa Rica. And I continue to care for my astronauts and the cohorts, and I believe this is the center for that I refer them to, for regenerative care, for musculoskeletal and for longevity.
My trust in this team is. personal, because I’ve gone through many of their, uh, interventions, many of their therapies. It’s an integrated team that looks at nutrition, that looks at musculoskeletal, it looks at brain health, looks at cognitive function, and they actually measure all these, these parameters and give you the biomarkers.
Dave Asprey
I like RMI because they are backed by one of the most experienced and trustworthy longevity physicians on the planet.
Emily Johnson-Haug
This past Valentine’s Day (2025), I gave myself a profound gift: The entire experience surpassed my expectations in every way. I decided on the treatments somewhat last-minute while traveling in Costa Rica, and the RMI team was exceptionally accommodating in scheduling. From the moment I arrived, I was met with a comfortable environment and a staff that made me feel truly seen and cared for. The procedure itself was smooth, efficient, and remarkably streamlined. For anyone considering these advanced treatments, I cannot recommend RMI highly enough—their professionalism and patient-centered approach are truly exceptional.
Marc Kielberger
My experience at RMI has been truly transformative. From the very first visit, the level of care,
professionalism, and personalized attention has been exceptional. Over the years, I’ve experienced the life-changing benefits of a wide range of RMI’s advanced regenerative and longevity-focused therapies.
The team combines world-class expertise with genuine humanity- you are listened to, educated, and supported at every step. RMI truly sets the gold standard in regenerative and longevity medicine.
Liam Harrison
I’ve done my last two fight camps in absolute agony. When I finally got an MRI, the news wasn’t good: a big SLAP tear in my labrum, bad degeneration, and arthritis. I knew I needed to do something before the injury turned into something more sinister.
I went to RMI and we hammered the areas that were struggling.
The experience I received at RMI worked an absolute dream. They didn’t just manage my pain; they actually helped my body repair itself. They are the reason I’m going to be back on the mats and back where I left off far sooner than anyone expected.
Troy Hoffman
The experience, the Doctors on staff . The before and after care . They have it nailed down here .. compared to all the places I went in Cancun and Baja peninsula.
Emily Johnson-Haug
This past Valentine’s Day (2025), I gave myself a profound gift: The entire experience surpassed my expectations in every way. I decided on the treatments somewhat last-minute while traveling in Costa Rica, and the RMI team was exceptionally accommodating in scheduling. From the moment I arrived, I was met with a comfortable environment and a staff that made me feel truly seen and cared for. The procedure itself was smooth, efficient, and remarkably streamlined. For anyone considering these advanced treatments, I cannot recommend RMI highly enough—their professionalism and patient-centered approach are truly exceptional.
Smith Johnston
Dr. Urzola and Dr. Giampapa have built what I consider the leading regenerative medicine institute in the world. It’s called Regenerative Medicine Institute in Costa Rica. And I continue to care for my astronauts and the cohorts, and I believe this is the center for that I refer them to, for regenerative care, for musculoskeletal and for longevity.
My trust in this team is. personal, because I’ve gone through many of their, uh, interventions, many of their therapies. It’s an integrated team that looks at nutrition, that looks at musculoskeletal, it looks at brain health, looks at cognitive function, and they actually measure all these, these parameters and give you the biomarkers.
Liam Harrison
I’ve done my last two fight camps in absolute agony. When I finally got an MRI, the news wasn’t good: a big SLAP tear in my labrum, bad degeneration, and arthritis. I knew I needed to do something before the injury turned into something more sinister.
I went to RMI and we hammered the areas that were struggling.
The experience I received at RMI worked an absolute dream. They didn’t just manage my pain; they actually helped my body repair itself. They are the reason I’m going to be back on the mats and back where I left off far sooner than anyone expected.
Dave Asprey
I like RMI because they are backed by one of the most experienced and trustworthy longevity physicians on the planet.
Marc Kielberger
My experience at RMI has been truly transformative. From the very first visit, the level of care,
professionalism, and personalized attention has been exceptional. Over the years, I’ve experienced the life-changing benefits of a wide range of RMI’s advanced regenerative and longevity-focused therapies.
The team combines world-class expertise with genuine humanity- you are listened to, educated, and supported at every step. RMI truly sets the gold standard in regenerative and longevity medicine.
1800+
Care provided across orthopedics, longevity, and chronic care programs.
15+
Delivering regenerative and longevity care through clinical practice.
92%
Based on post-care feedback and experience assessments.
80%+
Average viable cell yield measured during laboratory preparation.